According to the WHO data, preeclampsia develops during late pregnancy in 2-8% of women. Preeclampsia is a major cause of maternal and perinatal morbidity and mortality, therefore, the study of the morphological features of placental complex, taking into account gestational complications in postpartum women with severe preeclampsia is an important factor for finding the optimal treatment during pregnancy. The study was conducted on a placental complex (placenta, umbilical cord, fetal membranes) obtained from 24 pregnant women (10 pregnancies without complications, 14 with severe preeclampsia) of the first maternity home in Aktobe city. Paraffin histological sections were stained with hematoxylin - eosin and by using Van Gieson's stain. In the presence of severe preeclampsia, villi walls of separate blood vessels are sclerotic; sometimes vessels are dilated and filled with blood. Areas of eosinophilic accretions on the surface of the chorionic plate increased significantly, up to 15,9 ± 0,6%, areas of Langhans fibrinoid contacting terminal villi - up to 15,3 ± 1,2%. Rohr area on the basal lamina increased up to 21,1 ± 1,1%, along with increase in the number and area of decidual cells - up to 11,3 ± 1,14%. There was an increase in the number and area of terminal villi, up to 4,6 ± 0,45%. Arterial blood vessels of the umbilical cord lost annular invagination rolls into the lumen of the vessel. The study showed consolidation and infiltration of cellular elements of the fetal membranes. In response to strengthening of the destructive processes (inflammation, apoptosis), one could observe more pronounced compensatory and adaptive processes in the form of strengthening fibrinoid barriers aimed at eliminating defects of the fetoplacental barrier and at increasing the number of terminal villi, in the development of placental insufficiency.

Anderson, U. D., Otsson, M. G., Kristensen, K. H., Akezstrom, B. & Hansson, S. R. (2012). Review: Biochemical markers to predict precclamsia. Placenta, 33, 42-47.

Belotserkovtseva, L. D., Kasparova, A. E., & Kovalenko, L. V. (2013). Preeclampsia (gestosis): disease pathogenesis, clinical manifestations, diagnosis, treatment and prevention. Surgut: Nauka-S, 352 p.

Cindrova-Davies, T. (2007). NF-kB, p38 and stress activated protein kinase mitogen-activated protein kinase signaling partways regulate proinflammotory cytokines and apoptosis in human placental explants in response to oxidative stress. The American Journal of Pathology, 170, 1511-1520.

Davison, J. M., Homuth, V., Jeuabalan, A. (2004). New aspesrs in the pathophysiology of preeclampsia. Journal of the American Society of Nephrology, 15, 2440-2448.

Dubova, E. A., Buranova, F. B., Fedorova, T. A., Shchegolev, F. I. & Sukhikh, G. T. (2013). Morphological characteristics of terminal villi in the presence of placental insufficiency. Bulletin of Experimental Biology and Medicine, 15(4), 505-510.

Ghulmiyyah, L., Sibai, B. (2012). Maternal mortality from preeclampsia. Eclamsia. Semin. Perinatal. 36(1), 56-59.

Kasparova, A. E. (2013). Indicators of adaptation and morbidity in neonates and children during the first years of life in the development of fetoplacental and cardioplacental insufficiency associated with preeclampsia and intrauterine infection. Questions of Practical Pediatrics, 8(3), 18-25.

Klimov, V. A. (2008). Endothelium of fetoplacental complex during physiological and pathological pregnancy. Obstetrics and gynecology, 2, 7-9.

Kolesnikov, S. I., Paraskun, V. G., & Martynov, V. I. (1975). Morphological aspects of the mother - fetus system adaptation. Research papers of Novosibirsk State Medical University, 80, 12-85.

Matthiesen, L. (2005). Immunology of preeclampsia. Immunol. Pregnancy, 89, 49-61. 

Medvedev, N. I. (2008). Late %: Clinical - laboratory control. The success of modern natural science, 9, 94-96.

Murphy, M. S., Casselman, R. C., Tayade, C., & Smith, G. N. (2015). Differential expression of plasma mikro RN/A in preeclamptic patients at delivery and 1 year postpartum. American journal of obstetrics and gynecology, 1, 217-221.

Niyazyaeva, N. V., Volkova, Y. S., Mullabaeva, S. M., & Shchegolev, A. I. (2014) Methodical bases of placental tissue studies and pretreatment material optimization. Obstetrics and gynecology, 8, 11-18.

Orazmuradov, A. A., Apresian, S. V., & Radzinsky, V. E. (2009). Placental insufficiency: realities and prospects. Moscow: Status Praesens, 436 p.

Serov, V. N., Sukhikh, G. T. (2014). Clinical guidelines. Obstetrics and gynecology. Moscow: GEOTAR –Media, 311 p.

Shchegolev, A. I., Dubova, E. A., Pavlov, K. A., Lyapin, V. M., Kulikova, G. V., & Shmikov, R. G. (2012). Morphological characteristics of placental terminal villi in the presence of preeclampsia. Bulletin of Experimental Biology and Medicine, 154(7), 104-107.

Sidorova, I. S., Filippov, O. S., Nikitina, N. A., & Guseva, E. V. (2015). Causes of maternal deaths from preeclampsia and eclampsia in Russia in 2013. Obstetrics and gynecology, 4, 11-17.

Sidorova, I. S., Milovanov, A. P., Nikitina, N. A., & Rzayeva, A. A. (2014). Pathomorphological features of brain damage in the presence of severe preeclampsia and eclampsia. Obstetrics and gynecology, 3, 44-48.

Sidorova, N. S. & Nikitina, N. A. (2014). Preeclampsia in the focus of practicing physician. Obstetrics and gynecology, 6, 4-9.

Strizhakov, A. N., & Ignatko, I. V. (2007). Loss of pregnancy. Moscow: MIA, 364 p.

World Health Organization (2011). WHO Recommendations for preventions for prevention and treatment of prfe-eclampsia and eclampsia. Geneva, 38 p.