The search for new methods for treating duct-destructive pancreatitis is a relevant problem. Endogenous intoxication and oxidative stress that accompany acute pancreatitis often progress even after surgery, which forces one to search for additional possibilities of preventing these severe consequences. This research studied the effect of small doses of direct electric current and intravenous ozone therapy in combination with therapeutic omental pancreatic bursoscopy in the treatment and prevention of the infection of necrotic foci of the pancreas. The rate of postoperative complications in patients with infected pancreatic necrosis and the causes of death of patients with infected pancreatic necrosis were studied.

Banks, P. A., & Freeman, M. L. (2006). Practice Guidelines in Acute Pancreatitis. The American Journal of Gastroenterology 101(10), 23–79.

Banks, P. A., Bollen, Th. L., Dervenis, Ch., Gooszen, H. G., Johnson, C. D., Sarr, M. G., Tsiotos, G. G., & Vege, Santhi S. (2013). Classi Fi Cation of Acute Pancreatitis — 2012. Gut, 62(1), 102-11.

Beger, Hans G., & Rau Bettina M. (2007). Severe Acute Pancreatitis. Clinical Course and Management, 13(38), 5043–5051.

Bennett, G. L., & Balthazar, E. J. (1998). Imaging of Acute and Chronic Pancreatitis in Hepatobiliary and Pancreatic Radiology. In G.S. Gazelle, S. Sai, P.R. Mueller (Eds.). New York: Thieme, 1238 p.  

Bertin-Maghit, M., Goudable, J., Dalmas, E., Steghens, J. P., Bouchard. C., Gueugniaud, P. Y., Petit. P., & Delafosse, B. (2000). Time Course of Oxidative Stress after Major Burns. Intensive Care Medicine 26(6), 800–803.

Besselink, M. G., VanSantvoort, H. C., Boermeester, M. A., Nieuweohuijs, V. B., VanGoor, H., Dejong, C. H, C., Schaapherder, A. F., & Gooszen, H. G. (2009). Timing and Impact of Infections in Acute Pancreatitis. British Journal of Surgery 96(3), 267–273.

Boyko, V. V., Krivoruchko, I. A., Shevchenko, R. S., Smachilo, R. M., & Pesotsky, O. N. (2002). Acute Pacreatitis. Pathophysiology and Treatment, 7, 47-52.

Bradley, E. L. (1993). Clinically Based Classification System for Acute Pancreatitis. Arch Surg, 128, 111-121.

Büchler, M. W., Gloor, B., Müller Ch. A., Friess, H., Seiler, Ch. A., & Waldemar, Uhl. (2000). Acute Necrotizing Pancreatitis: Treatment Strategy according to the Status of Infection. Annals of Surgery, 232(5), 619–626.

Chak, A., Hawes R. H., Cooper, G. S., Hoffman, B., Catalano, M. F, Wong, R. C. K., Herbener, Th. E., & Sivak M. V. (1999). Prospective Assessment of the Utility of EUS in the Evaluation of Gallstone Pancreatitis. Gastrointestinal Endoscopy 49(5), 599–604.

Connor, S., Raraty, M. G. T., Howes. N., Evans, J., Ghaneh, P., Sutton, R., & Neoptolemos, J. P. (2005). Surgery in the Treatment of Acute Pancreatitis. Scandinavian Journal of Surgery, 94(6), 135–142.

Dröge, W. (2002). Free Radicals in the Physiological Control of Cell Function. Physiological Reviews 82(1), 47–95.

Ersoz, N., Ozler, M., Topal, T., Uysal, B., Poyrazoglu, Y., Simsek, K., Gocgeldi, E., & Korkmaz, A. (2016). The Effect of Ozone Treatment on Experimental Colon Anastomosis in Rats. European Surgery 48(2), 122–128.

Ferreira, F. L., Bota, D. P., Bross, A., Mélot, Ch., & Vincent, J. L. (2001). Serial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients. Jama 286(14), 1754–1758.

Forman, H. J., Augusto, O., Brigelius-Flohe, R., Dennery, Ph. A., Kalyanaraman, B., Ischiropoulos, H., Mann, G. E., Radi, R., Roberts, L. J., & Vina, J. (2015). Even Free Radicals Should Follow Some Rules. Free Radical Biology and Medicine 78, 233–235.

Gabrielyan, N. I., Savostyanova, O. A., Gorskaya, Ye. M., & Poptsov, V. I. (2011). The Significance of Postoperative Measurement of the Middle Molecular Weight as a Predictor of Suppurative Septic Infections in Cardiac Surgery Patients. Epidemiology and Infectious Diseases, 1, 20–25.

Halliwell, B., & Chirico, S. (1993). Lipid Peroxidation. The American Journal of Clinical Nutrition, 57(5), 715–724.

Herath, H. M., & Kulatunga, A. (2016). Acute Pancreatitis Complicated with Deep Vein Thrombosis and Pulmonary Embolism. Journal of Medical Case Reports, 10, 253-267.

Kaliev, A. A., Zhakiev, B. S., Eleulov, G. A., & Konakbaeva, N. K. (2013). Concomitant Use of Intravenous Ozone Therapy and Small Doses of Direct Current in the Integrated Treatment of Patient with Sterile Pancreatic Necrosis. Proceedings of the Russian Academy of Medical Sciences/Russian Academy of Medical Sciences, 1(2), 16–18.

Karakayali, F. Y. (2014). Surgical and Interventional Management of Complications Caused by Acute Pancreatitis. World Journal of Gastroenterology,  20(37), 134-142.

Knaus, W. A, Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985). A Severity of Disease Classification System. Critical Care Medicine, 13(10), 818–829.

Knaus, W. A., Wagner, D. P., Draper, E. A., Zimmerman, J. E., Bergner, M., Bastos, P. G., Sirio, C. A, Murphy, D. J., Lotring, T., & Damiano, A. (1991). Prognostic System. Risk Prediction of Hospital Mortality for Critically Hospitalized Adults. Chest Journal, 100(6), 1619–1636.

Lankisch, P. G., Assmus, C., Maisonneuve, P., & Lowenfels, A. B. (2002). A Study in a Defined German Population. Pancreatology, 2(5), 469–477.

Larvin, M. & Mcmahon M. J. (1989). Score for Assessment and Monitoring of Acute Pancreatitis. The Lancet, 334, 201–205.

Li, Q., Bai Z., Xueyan Z., Chendlin P., Wenpeng C., Wang Y., Jing S., Wenguo C., & Wenpeng, M. (2016). Treatment of Necrotizing Acute Pancreatitis with Peritoneal Lavage and Dialysis by a New Simpli Fi Ed Technique Insert Catheters. Medicine, 95(23), 214–226.

Lindkvist, B., Appelros, S., Manjer, J., & Borgström, A. (2004). Trends in Incidence of Acute Pancreatitis in a Swedish Population: Is There Really an Increase? Clinical Gastroenterology and Hepatology 2(9), 831–837.

Maher, M. M., Lucey, B. C., Gervais, D. A., & Mueller, P. R. (2004). Acute Pancreatitis: The Role of Imaging and Interventional Radiology. Cardiovascular and Interventional Radiology, 27, 208–225.

Mikolasevic, I., Milic, S., Orli,c L., Poropat, G., Jakopcic, I., Franjic, N., Klanac, A., Kristo, N., & Stimac, D. (2016). European Journal of Internal Medicine Metabolic Syndrome and Acute Pancreatitis. European Journal of Internal Medicine., 12(2), 245-252.

Nikolskaya, V. A., Danilchenko, Yu. D., & Memetova Z. N. (2013). The Biochemical Aspect of the Role of Middle Molecular Mass in the Organism. Scientific Notes of the Community of the V.I. Vernadsky Tavrida National University, 5, 145-152.

Nydegger, A., Heine, R. G., Ranuh, R., Gegati-levy, R., Crameri, J., & Oliver, M. R. (2007). Changing Incidence of Acute Pancreatitis. Gastroenterology 22: 1313–1316.

Ostrovskiĭ, V. K., Alimov, R. R., Mashchenko, A. V., Semenova, O. P., & Kurapova, M. I. (2003). Normal Parameters of Leukocyte Index of Intoxication. Clinical Laboratory Diagnostics, 1, 45–46.

Pankhurst, Q. A., Connolly, J., Jones, S. K., & Dobson J. (2003). Applications of Magnetic Nanoparticles in Biomedicine. Journal of Physics, 36, 167–181.

Papachristou, G. I., Muddana, V., Yadav, D., Connell, M. O., & Sanders, M. K. (2010). Comparison of BISAP , Ranson’s, APACHE-II , and CTSI Scores in Predicting Organ Failure, Complications, and Mortality in Acute Pancreatitis. The American Journal of Gastroenterology 105, 435–441.

Pereslegina, I. A. (1989). The Activity of Antioxidant Enzymes in the Saliva of Healthy Children. Laboratory Studies, 11, 20–23.

Ranson, J. H. (1979). The Timing of Biliary Surgery in Acute Pancreatitis. Annals of Surgery 189(5), 654.

Schwartz, J., Winters, J. L., Padmanabhan, A., Balogun, R. A., Delaney, M., Linenberger, M. L., Szczepiorkowski, Z. M., Williams, M. E., Wu Yanyun, & Shaz, B. H. (2013). Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence‐Based Approach from the Writing Committee of the American Society for Apheresis. Journal of Clinical Apheresis 28(3), 145–284.

Sheĭko, V. D., & Oganezian A. H. (2013). The Optimization of Surgical Tactics in Local Accumulations of Liquid in Patients with Severe Acute Pancreatitis. Ministry of Healthcare of Ukraine, Scientific Community of Surgeons of Ukraine, 12, 22–24.

Spanier, B. W., Dijkgraaf, M. G., & Bruno M. J. (2008). Epidemiology, Aetiology and Outcome of Acute and Chronic Pancreatitis. Best Practice & Research Clinical Gastroenterology 22(1), 45–63.

Tenner, S., Baillie, J., DeWitt, J., & Vege, S. S. (2013). American College of Gastroenterology Guideline. Am J Gastroenterol, 108(9), 140–152.

Tinto, A., Lloyd D. A. J., Kang, J.-Y., Majeed, A., Ellis, C., Williamson, R. C., & Maxwell, J. D. (2002). Acute and Chronic Pancreatitis-Diseases on the Rise. Alimentary Pharmacology & Therapeutics, 16(12), 97–105.

Tokar, J. L., Barth, B. A., Banerjee, S., Chauhan, Sh. S., Gottlieb, K. T, Konda, V., Maple, J. T., Murad, F. M., Pfau, P. R., & Pleskow, D. K. (2013). Electrosurgical Generators. Gastrointestinal Endoscopy, 78(2), 197–208.

VanSonnenberg, E., Wittich, G. R., Casola, G., Brannigan, T. C., Karnel, F., Stabile, B. E., Varney, R. R., & Christensen, R. R. (1989). Percutaneous Drainage of Infected and Noninfected Pancreatic Pseudocysts. Radiology, 170(3), 757–761.

Vinokurov, M. M., Savel’ev, V. V., & Ammosov, V. G. (2008). Advantages and Disadvantages of Various Surgical Tactics in Treatment of Infected Pancreatic Necrosis. Surgery, 11, 23–26.

Volchegorsky, I. A., Dolgushin, I. I., Kolesnikov, O. L., & Tseylikman, V. E. (2000). Experimental Modeling and Laboratory Assessment of the Organism's Adaptation Responses. Chelyabinsk: Mir, 167 p.

Voskanyan, S. E., Kotenko, K. V., Korsakov, I. N., & Naydenov, E. V. (2013). Prediction of the Acute Pancreatitis after Surgery on the Pancreas. Experimental & Clinical Gastroenterology, 9, 61–68.

Wu, B. U., Johannes, R. S., Xiaowu S., Ying T., Conwell, D. L, & Banks, P. A. (2008). The Early Prediction of Mortality in Acute Pancreatitis. Gut 57(12), 1698–1703.

Yousaf, M., McCallion, K., & Diamond, T. (2003). Management of Severe Acute Pancreatitis. British Journal of Surgery 90(4), 407–420.

Zerem, E. (2014). Treatment of Severe Acute Pancreatitis and Its Complications. World Journal of Gastroenterology 20(38), 13879–13892.