Knowledge and science process skills are important in the science classroom. Science processes are thinking processes that foster lifelong learning. In inquiry-based science learning, students are engaged in many of the activities and thinking processes that scientists use to produce new knowledge. The inquiry approach can be implemented effectively with the use of questions leading to an investigation through which students learn to understand the content of the subject. This study investigated the effectiveness of a question-based inquiry module (QBIM) for learning biological knowledge and science process skills. The research participants were 34 eight graders of junior high school. The results showed biological knowledge and science process skills of students were mostly in the good category. The effectiveness index (EI) of biological knowledge and science process skills were 85.29 % and 79.41% respectively. The students' responses to the implementation of QBIM were positive. The students stated that they enjoyed learning biology (91.18%), the learning was considered attractive (97.06%), the module was easy to learn (85.29%), the tasks were challenging (85.29%), and the assessment was good (97.06). QBIM was an effective medium for teaching biological knowledge and science process skills. The findings of this study also pointed out the students’ positive responses to the QBIM-based science learning.  

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