The relevance of the analyzed issue is caused by the growing slippage of research funds of sustainable development in its practice. The purpose of the article is the theoretical basis of the biosphere reserve as a scientific research subject that is relevant to rules of the scientific activity. The leading approach to the study of this issue is the use of the theoretical and active approach. Tools of this methodological approach can determine the subject and content of the main “blocks” of the scientific subject – “the biosphere reserve”. Results of the research include: 1 - the analysis of the previous use of the organizational form of “the biosphere reserve”; 2 - the actual rationale for its purpose. This research justifies the function of the biosphere reserve as a scientific subject of applied research for sustainable development. The authors also justify a particular object (“activity” as opposed to “nature”) for the subject of “the biosphere reserve”. The contents of the article may be useful for specialists in the field of the scientific research methodology and regulatory support of sustainable development.

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